GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4925540 | 1 | rs4971319 | chr1:247211565 | OR2W3 | chr1:248031265-248060142:+ | -0.18 | -3.62 | 0.000328 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs4925540 | 1 | rs4971319 | chr1:247211565 | TRIM58 | chr1:248020501-248043436:+ | -0.15 | -3.38 | 0.000771 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs599083 | 1 | rs497261 | chr11:68192244 | LOC645332 | chr11:67559240-67572807:- | 0.16 | 3.5 | 0.000514 | Bone mineral density (spine) |
| THCA | cis | rs9815354 | 1 | rs4973991 | chr3:41927273 | ULK4 | chr3:41288091-42003660:- | -1.09 | -20.92 | 1.8E-69 | Diastolic blood pressure |
| THCA | cis | rs1031925 | 1 | rs4974105 | chr3:51369574 | HEMK1 | chr3:50606583-50622419:+ | 0.2 | 4.18 | 3.4E-5 | Melanoma |
| THCA | cis | rs1031925 | 1 | rs4974105 | chr3:51369574 | TEX264 | chr3:51705222-51738338:+ | -0.22 | -6.05 | 2.93E-9 | Melanoma |
| THCA | cis | rs10935120 | 1 | rs4974483 | chr3:134219001 | ANAPC13 | chr3:134196547-134204865:- | 0.37 | 11.71 | 4.87E-28 | Height |
| THCA | cis | rs10935120 | 1 | rs4974483 | chr3:134219001 | CEP63 | chr3:134204575-134293852:+ | 0.29 | 6.38 | 4.28E-10 | Height |
| THCA | cis | rs10935120 | 1 | rs4974484 | chr3:134219019 | ANAPC13 | chr3:134196547-134204865:- | 0.39 | 12.35 | 1.27E-30 | Height |
| THCA | cis | rs10935120 | 1 | rs4974484 | chr3:134219019 | CEP63 | chr3:134204575-134293852:+ | 0.29 | 6.33 | 5.5E-10 | Height |
| THCA | cis | rs10935120 | 1 | rs4974493 | chr3:134219993 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 12.84 | 1.2E-32 | Height |
| THCA | cis | rs10935120 | 1 | rs4974493 | chr3:134219993 | CEP63 | chr3:134204575-134293852:+ | 0.29 | 6.27 | 8.12E-10 | Height |
| THCA | cis | rs4974559 | 1 | rs4974559 | chr4:1380848 | CRIPAK | chr4:1385340-1389782:+ | -0.34 | -7.05 | 6.31E-12 | Systolic blood pressure |
| THCA | cis | rs1061377 | 1 | rs4974931 | chr4:39110516 | KLHL5 | chr4:39046659-39123828:+ | -0.21 | -5.75 | 1.55E-8 | Uric acid levels |
| THCA | cis | rs1061377 | 1 | rs4974997 | chr4:39110771 | KLHL5 | chr4:39046659-39123828:+ | -0.21 | -5.77 | 1.46E-8 | Uric acid levels |